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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">eifc</journal-id><journal-title-group><journal-title xml:lang="ru">Эпизоотология Иммунобиология Фармакология Санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Epizootology Immunobiology Pharmacology Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-168X</issn><publisher><publisher-name>Институт экспериментальной ветеринарии им. С.Н. Вышелесского</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">eifc-12</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ФАРМАКОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>FARMACOLOGY</subject></subj-group></article-categories><title-group><article-title>Токсикологическая характеристика нового поликомпонентного противомаститного препарата «Мастин» для лечения мастита у коров</article-title><trans-title-group xml:lang="en"><trans-title>Toxicological characterization of new multicomponent antimastitis preparation «Mastin» for the treatment of mastitis in cows</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Степанова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Stepanova</surname><given-names>E. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьминский</surname><given-names>И. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuzminski</surname><given-names>I. I.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лиленко</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lilenko</surname><given-names>A. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Богуш</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bogush</surname><given-names>A. A.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трофимов</surname><given-names>А. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Trofimov</surname><given-names>A. F.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>РУП «Институт экспериментальной ветеринарии им. С.Н. Вышелесского»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2018</year></pub-date><volume>0</volume><issue>1</issue><fpage>59</fpage><lpage>62</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Степанова Е.А., Кузьминский И.И., Лиленко А.В., Богуш А.А., Трофимов А.Ф., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Степанова Е.А., Кузьминский И.И., Лиленко А.В., Богуш А.А., Трофимов А.Ф.</copyright-holder><copyright-holder xml:lang="en">Stepanova E.A., Kuzminski I.I., Lilenko A.V., Bogush A.A., Trofimov A.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://eifc.belal.by/jour/article/view/12">https://eifc.belal.by/jour/article/view/12</self-uri><abstract><p>В статье представлены сведения о токсикологической характеристике нового комплексного препарата «Мастин» для лечения мастита у коров, приведены данные по определению его токсичности, описан опыт по определению хронической токсичности препарата на лабораторных животных. Установлено, что среднесмертельная доза (ЛД50) поликомпонентного противомаститного препарата при пероральном введении для белых мышей составила 37 250,55 мг/кг массы тела. Препарат относится к веществам малоопаснъм (IV класс) с LD50 более 5000 мг/кг.</p></abstract><trans-abstract xml:lang="en"><p>Data on the toxicological characteristics of the new complex preparation «Mastin» for the treatment of mastitis in cows are presented in the article, data on determination of its toxicity are given, еxperience on determination of chronic toxicity of preparation on laboratory animals is described. It was found that LD50 of the antimastitis drug at the oral dose for white mice was 37 250,55 mg / kg of body weight. The drug is a low-risk substance (IV class) with LD50 more than 5000 mg/kg.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
