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<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">eifc</journal-id><journal-title-group><journal-title xml:lang="ru">Эпизоотология Иммунобиология Фармакология Санитария</journal-title><trans-title-group xml:lang="en"><trans-title>Epizootology Immunobiology Pharmacology Sanitation</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2224-168X</issn><publisher><publisher-name>Институт экспериментальной ветеринарии им. С.Н. Вышелесского</publisher-name></publisher></journal-meta><article-meta><article-id custom-type="elpub" pub-id-type="custom">eifc-53</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИММУНОБИОЛОГИЯ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>IMMUNOBIOLOGY</subject></subj-group></article-categories><title-group><article-title>Влияние приобретенной in vitro резистентности Klebsiella pneumoniaе к цефепиму на патогенные свойства и элиминацию бактерий факторами иммунитета</article-title><trans-title-group xml:lang="en"><trans-title>Influence of acquiering in v itro resistance of Klebsiella pneumoniae to sephepim on pathogenic properties and bacteriaʼs elimination by immunity factores</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>O. N.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ломако</surname><given-names>Ю. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lomako</surname><given-names>Y. V.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Белянко</surname><given-names>Д. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Belianko</surname><given-names>D. L.</given-names></name></name-alternatives><email xlink:type="simple">noemail@neicon.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>РУП «Институт экспериментальной ветеринарии им. С.Н. Вышелесского»</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>30</day><month>12</month><year>2019</year></pub-date><volume>0</volume><issue>2</issue><fpage>44</fpage><lpage>48</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новикова О.Н., Ломако Ю.В., Белянко Д.Л., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Новикова О.Н., Ломако Ю.В., Белянко Д.Л.</copyright-holder><copyright-holder xml:lang="en">Novikova O.N., Lomako Y.V., Belianko D.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://eifc.belal.by/jour/article/view/53">https://eifc.belal.by/jour/article/view/53</self-uri><abstract><p>Приобретенная in vitro резистентность Klebsiella pneumoniae к цефепиму изменяет клиренс бактерий гранулоцитами и повышает чувствительность к бактерицидным факторам сыворотки крови морской свинки. Цефепим изменяет поверхностную структуру K. pneumoniae, способствуя повышению специфического иммунного ответа у морских свинок. Приобретенная in vitro резистентность K. pneumoniae к цефепиму нестабильна.</p></abstract><trans-abstract xml:lang="en"><p>Acquiering in vitro resistance of K. pneumoniae to sephepim change granulocyte dependent clearance of bacteria and enhance sensibility to bactericid activity of guinea pig, s blood serum. It was shawn that sephepim change surface structure of K. pneumoniae promote enhance of specific immune response in guinea pig. Acquiering in vitro resistance of K. pneumoniae to sephepim is unstable.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
