Investigation of the connection of lymphosarcoma with latent tuberculosis infection
https://doi.org/10.47612/2224-168X-2021-2-40-53
Abstract
DNA and antigens of mycobacteria tuberculosis (MBT) were detected in the cells of the tissues of a goat that fell with signs of lymphosarcoma (sharp hyperplasia of the lymph nodes and spleen, a positive AGID with an antigen or the diagnosis of leukemia - FLK - BLV- bovine leukemia virus). Latent tuberculosis infection was confirmed by the isolation of non-acid – fast MBT (cell wall-cell wall deficient – CWD) from decontaminated and filtered through a sterilizing filter of lymph node and spleen homogenates. In the populations of CWD MBT from lymphosarcomatous tissues a number of characteristic cell varieties were present which were previously found in isolates from the blood of a tuberculin-positive goat of the same herd, from the lymph node of a BLV-seropositive cow and directly from FLK-BLV.
In the isolates of lymphosarcomatous tissues along with MBT antigens, antigens that reacted with antibodies to BLV and had the same molecular weight as BLV antigens were found, which indicated the existence of a connection between virus-like forms of MBT and oncogenesis.
About the Authors
A. P. Lysenko
РУП «Институт экспериментальной ветеринарии им. С.Н. Вышелесского»
Belarus
Belarus
M. V. Kuchvalsky
Белорусский государственный университет
Belarus
Belarus
E. L. Krasnikova
РУП «Институт экспериментальной ветеринарии им. С.Н. Вышелесского»
Belarus
Belarus
E. I. Jacobson
Белорусский государственный университет
Belarus
Belarus
References
1. US Department of Agriculture Animal and Plant Health Services, Veterinary Services, Center for Epidemiology and Animal Health. Info sheet : bovine leukosis virus (BLV) on U.S. dairy operations. – 2007.
2. Schwartz, I. Pathobiology of bovine leukemia virus / I. Schwartz, D. Lévy // Veterinary Research. – 1994. – Vol. 25. – № 6. – P. 521–536.
3. Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel antiretroviral therapies in human / N. Gillet [et al.] // Retrovirology. – 2007. – Vol. 4. – № 1. – P. 18.
4. Burridge, M. J. The zoonotic potential of bovine leukemia virus / M. J. Burridge // Veterinary Research Communications. – 1981. – Vol. 5. – № 1. – P. 117–126.
5. Choi, K. Y. Relative sensitivity and specificity of agar gel immunodiffusion, enzyme immunosorbent assay, and immunoblotting for detection of anti-bovine leukemia virus antibodies in cattle / K. Y. Choi, R. B. Liu, G. C. Buehring // Journal of Virological Methods. – 2002. – Vol. 104. – № 1. – P. 33–39.
6. Buehring, G. C. Humans Have Antibodies Reactive with Bovine Leukemia Virus / G. C. Buehring,
7. S. M. Philpott, K. Y. Choi // AIDS Research and Human Retroviruses. – 2003. – Vol. 19. – № 12. – P. 1105–1113.
8. Bovine Leukemia Virus DNA in Human Breast Tissue / G. C. Buehring [et al.] // Emerging Infectious Diseases. – 2014. – Vol. 20. – № 5. – P. 772–782.
9. Exposure to Bovine Leukemia Virus Is Associated with Breast Cancer: A Case-Control Study / G. C. Buehring [et al.] // PloS One. – 2015. – Vol. 10. – № 9. – P. e0134304.
10. Bovine leukemia virus linked to breast cancer in Australian women and identified before breast cancer development / G. C. Buehring [et al.] // PloS One. – 2017. – Vol. 12. – № 6. – P. e0179367.
11. Gillet, N. A. Whole genome sequencing of 51 breast cancers reveals that tumors are devoid of bovine leukemia virus DNA / N. A. Gillet, L. Willems // Retrovirology. – 2016. – Vol. 13. – № 1. – P. 75.
12. Livingston V. Cancer : a new breakthrough / V. Livingston, V. Wuerthele-Caspe. – Los Angeles : Nash Publishing, 1972. – 269 p.
13. Further evidence for cancer as cell-wall-deficient mycobacterial disease / A. P. Lysenko [et al.] // Journal of Molecular Pathological Epidemiology. – 2016. – Vol. 1. – № 1. – P. 1–12.
14. Вирус бычьего лейкоза – вирусоподобная форма микобактерий туберкулеза? / А. П. Лысенко [и др.] // Экология и животный мир. – 2019. – № 1. – С. 15–24.
15. Goat Lymphosarcoma From Bovine Leukemia Virus / C. Olson [et al.] // JNCI : Journal of the National Cancer Institute. – 1981. – Vol. 67. – № 3. – P. 671–675.
16. Выявление микобактерий туберкулеза в тканях с помощью дифференцирующей иммунопероксидазной окраски / А. П. Лысенко [и др.] // Туберкулез и болезни легких. – 2014. – № 10. – С. 55–58.
17. Власенко, В. В. Туберкулез в фокусе проблем современности / В. В. Власенко. – Винница : Наука, 1998. – 350 с.
18. Феномен изменчивости микобактерий туберкулеза и его использование для обнаружения туберкулезной инфекции / А. П. Лысенко [и др.] // Туберкулез – глобальная катастрофа человечества : материалы I Междунар. заочной науч.-практ. конф., 24 марта 2014 г. / Ростов-на-Дону : РостГМУ, 2014. – С. 176–198.
19. Вероятная связь миелоидного и лимфобластного лейкоза с туберкулезной инфекцией / А. П. Лысенко [и др.] // Эпизоотология, иммунобиология, фармакология, санитария. – 2020. – № 1. – C. 55–58.
20. Diller, I. Cytological studies of relationships between microorganisms isolated from tumor tissue and normal and malignant cells of the host / I. Diller // Cancer Research. – 1952. – № 12. – P. 257.
21. Дорожкова, И. Р. Скрыто протекающая туберкулезная инфекция / И. Р. Дорожкова, З. С. Земскова. – М. : Медицина, 1984. – 222 с.
22. Живильне середовище «Влакон» для експрес-диагностики туберкулезу / В. В. Власенко [и др.] // Науковий вiсник Львiвськой Национальноi академii ветеринарноi медицини iм. С. З. Гжицького. – 2005. – Т. 7. – № 1. – С. 56–60.
23. Markova N. Cell Wall Deficiency in Mycobacteria : Latency and Persistence / N. Markova // Understanding Tuberculosis – Deciphering the Secret Life of the Bacilli / ed. P.-J. Cardona. – InTech, 2012. – Cell Wall Deficiency in Mycobacteria. – P. 1–35.
24. Микобактерии туберкулеза при термическом воздействии образуют защитные формы, проходящие через ультрафильтры и восстанавливающие жизнеспособность в виде CWD форм / А. П. Лысенко [и др.] // Эпизоотология, иммунобиология, фармакология, санитария. – 2019. – № 1. – С. 33–45.
25. Tian, Y. Detection of Mycobacterium tuberculosis L-forms and MPB64 gene in breast cancer tissues / Y. Tian, X. K. Cui, T. Hao // J. of Practical Medicine. – 2013. – № 15. – P. 45–46.
26. Clinical end-points associated with Mycobacterium tuberculosis and lung cancer : implications into host-pathogen interaction and coevolution / Y. Tian [et al.] // BioMed Research International. – 2015. – Vol. 2015. – P. 1–9.
27. Ferran, J. La nueva bacteriologia de la tuberculosis : Congreso de la Tuberculosis / J. Ferran. – Valencia : Litografia de Jose Ortega, 1912. – 51 p.
28. Lung carcinogenesis induced by chronic tuberculosis infection: the experimental model and genetic control / A. Nalbandian [et al.] // Oncogene. – 2009. – Vol. 28. – № 17. – P. 1928–1938
Review
For citations:
Lysenko A.P., Kuchvalsky M.V., Krasnikova E.L., Jacobson E.I. Investigation of the connection of lymphosarcoma with latent tuberculosis infection. Epizootology Immunobiology Pharmacology Sanitation. 2021;(2):40-53. (In Russ.) https://doi.org/10.47612/2224-168X-2021-2-40-53
Views: 125
Email this article 