Study of hematological parameters and phagocytic activity of blood leukocytes during experimental infection of white mice with Costridium perfringens
Abstract
The article presents the results of the study of changes in hematological parameters and phagocytic activity of white mice blood leukocytes during experimental infection with Clostridium perfringens. The obtained experimental results testify to the multidirectional influence of clostridium infectious load on changes in the blood composition of mice, especially in the early periods of observation; so infection of mice with a dose of 5,0×107 microbial cells/mouse causes a decrease in almost all studied hematological parameters. On the contrary, infection of mice with a dose of 5,0×105 microbial cells/mouse is accompanied by leukocytosis in the early period of observation and erythrocytosis in the late period of observation. The phagocytic activity of leukocytes, i.e. phagocytic index and the degree of completed phagocytosis in blood leukocytes, decreased regardless of the dose of Clostridium perfringens infectious load.
About the Authors
O. N. Novikova
RUE "S.N. Vyshelessky Institute of Experimental Veterinary Medicine"
Belarus
Belarus
Candidate of Veterinary Sciences, Associate Professor
Minsk
M. A. Ananchikov
RUE "S.N. Vyshelessky Institute of Experimental Veterinary Medicine"
Belarus
Belarus
Candidate of Veterinary Sciences, Associate Professor
Minsk
O. N. Gordievskaya
RUE "S.N. Vyshelessky Institute of Experimental Veterinary Medicine"
Belarus
Belarus
junior research assistant
Minsk
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Review
For citations:
Novikova O.N., Ananchikov M.A., Gordievskaya O.N. Study of hematological parameters and phagocytic activity of blood leukocytes during experimental infection of white mice with Costridium perfringens. Epizootology Immunobiology Pharmacology Sanitation. 2024;(1):25-28. (In Russ.)
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