Mycobacteria of tuberculosis with a cell deficient wall are found in a brain of goats with spongiform changes

Abstract

Spongiform changes are found in a brain of the goats who have fallen with signs of damage of the central nervous system. In samples of a brain DNA and cell wall deficient mycobacteria are found, in cells of a brain and in intercellular space accumulation of mycobacterial antigens is noted. In spite of the fact that samples of a brain, were in 10% formalin 1 months, 3 and 5 years, in all cases cell wall deficient mycobacteria have been isolated. Their viability was comparable to infectivity of prions. Isolates cell wall deficient mycobacteria from a brain didn't differ on morphology and polypeptide profile from isolates from a tuberculin, FLK-BLV, lymph nodes of cows, suffering from tuberculosis. It indicates high probability that the mycobacterial infection depending on the infecting dose, features of a strain and owner's genome and also condition of immune system, can cause active tuberculosis, oncogene action, damages of a brain, cardiovascular system.