Toksikokinetik brom in the organism of white rats males in conditions of chronic receipt with the bromide sodium forage

Abstract

The article presents data on toxicokinetics of Bromine in the body of white male rats under conditions of long-term administration of Sodium Bromide diet. With a long-term administration of Bromine at a dose of 2,5 mg/kg body weight and 5,0 mg/kg body weight per day, the excess of element is excreted from the body through kidneys at the initial study period, as well as through digestive tract from the 30th day. Investigating the content of Bromine in the blood plasma, liver, spleen, heart, brain, pelvic muscle, and wool with rats’ skin in both experimental groups indicates a «material» cumulation of the element. Organs and tissues concentrators were skin and wool (max 140,77±3,15) mg/kg and liver (max 47,62±0,13) mg/kg.