Mycobacteria of tuberculosis after lethal influence of disinfectants can restore viability as cell wall deficient mycobacteria

Abstract

Mycobacterium bovis № 8 inactivated by disinfectants after an incubation in a growth stimulant and seed on the VKG nutrition medium restored viability as cell wall deficient mycobacteria CWD), capable after inoculation per os to persistence in an organism of mice. CWD M. bovis which restored viability from 5 cases, in 2 were resistant to «the» composition and in 3 - to «others». At repeated contacts they quickly formed resistance and to other disinfectants. It is believed that the process of restoring the viability and reproduction of CWD forms of mycobacteria can be slowed by the rotation of disinfectants. The antigenic structure at the CWD forms which restored viability did not differ from CWD isolates from the T lymphocytes of the person sick with T-lymphoblastoid leukemia (Jurkat) and from the fetal lamb kidney cells infected with the Bovine Leukemic Virus (FLK-BLV). It is assumed that CWD MBT getting to an organism from external environment can be risk factor of cancerogenesis.