Probable link between myeloid and lymphoblastic leukemia with tuberculosis infection

Abstract

From the cultures cells of myeloblasts of the human patient with acute myeloid leukemia (Kasumi-1) and T-lymphocytes the patient with T-lymphoblastic leukemia (Jurkat) including from 0.22 µm filtrates of cells lysates there are isolated mycobacteria of tuberculosis (MBT) with deficient cell wall (cell wall deficient - CWD) with the same of antigens composition. Isolates had a number of unique properties. After destruction by ultrasound and filtration through Amicon Ultracel® 100 K and Millex ® GP 0.22 µm their filtrates gave growth of CWD MBT having the same antigenic composition, including starting isolates. The main role in the isolation of CWD MBT was the incubation of the test material in the growth stimulants, sowing on a special nutrient medium and «blind» passages.