Pharmaco-toxicological profile of the drug «Metrafarm»

Abstract

The article presents data on pharmaco-toxicological characterization of a new veterinary preparation «Metrofarm».
The article describes the experience of determining acute toxicity of the drug, embryotoxic and teratogenic effects of the drug on laboratory animals.
The average lethal dose (LD₅₀) of the veterinary drug Metrafarm when administered orally for white mice was 62500 mg/kg of body weight. The drug belongs to low-hazard substances (class IV) with an LD₅₀ of more than 5000 mg/kg, according to GOST 12.1.007-76. The laboratory sample of the drug does not cause any deviations from the physiological norm in the clinical state in mice treated with the drug at doses of 1/10, 1/20 and 1/50 of the LD₅₀ dose.
It was found that the veterinary drug «Metrafarm» used in a toxic dose (30000,0 mg/kg body weight) to rats at various stages of pregnancy (periods of embryogenesis, organogenesis, fetal phylogeny and throughout the pregnancy period) does not cause pathological changes during pregnancy in rats, as well as deviations in the development of offspring, deformities, which indicates the absence of embryotoxic and teratogenic properties.