Brucellosis, like all infectious diseases common to animals and humans in modern conditions, can have an extremely serious negative impact on public welfare. In the 30s of the last century, brucellosis of farm animals was one of the serious problems in the BSSR. A set of health and preventive measures managed to eliminate the disease in the country by 1976. At the same time, an unfavorable situation is currently developing in the country regarding this infection, which requires taking appropriate measures. Of great importance in this direction will be the implementation of the provisions of the Concept of the National System for Ensuring Biological Safety adopted on March 22, 2022.

As a result of the studies, it was found that the accumulation of Bordetella bronchiseptica is maximum in GRM broth and Hottinger broth with the addition of 1% glutamine and 10% cattle serum.

A technique has been developed for isolating mesenchymal stem cells with a characteristic phenol- and immunotype from the adipose tissue of cattle. Research results show that adipose tissue (AT) of cattle is a source of mesenchymal stem cells (MSCs) that can be used in veterinary medicine.

The article presents the results on the effect of vaccine «Pastevir-R» on morphological blood parameters in cattle. It is established that the investigated vaccine has no negative effect on the general condition of animals and morphological blood parameters.

The article presents the results of studies using a PCR test system developed to detect the genome of Mannheimia haemolytica. The etiological significance of Mannheimia haemolytica, along with other pathogens that cause respiratory pathology in cattle, has been established. The pathogen Mannheimia haemolytica was detected in 11 of 38 farms studied (29 %). The percentage of pathogen isolation in manheimia-positive farms was 37 %. In most cases, M. haemolytica was isolated in association with other viral and bacterial infections.

The domestically developed anti-eimeriosis herbal preparations «Fitococcidin» and «Coccilin B plus» do not have a negative effect on the bird's body when used in broiler chickens. Their use normalizes metabolic processes, having a beneficial effect on protein, carbohydrate and mineral metabolism in the body of broiler chickens.

PCR is a powerful tool for molecular diagnostics, it is an important additional method that significantly improves the accuracy and speed of diagnostics of infectious diseases. Detection of the Clostridium perfringens genome by PCR indicates the presence of dysbacteriosis and the potential for the development of an infectious process. The diagnosis of anaerobic enterotoxemia should be established comprehensively taking into account epizootological data, anamnesis, clinical picture, results of microbiological research, results of PCR diagnostics (determine the toxinotypes of Clostridium perfringens taking into account the main toxins produced), results of pathological examination.

The article presents information on studying the acute toxicity of the veterinary preparation «Resovet» on laboratory animals and the preventive efficacy of «Resovet» in caring the gastrointestinal and respiratory tracts’ dis eases on broiler chickens. The obtained results indicate that according to the degree of impact on the animal’s body «Resovet» is classified at the 4th hazard class. LD₅₀ is above 5000 mg/kg. Oral use of «Resovet» is safe for broiler chickens. It helps preventing the bacterial diseases and has a positive effect on preserving the young poultry.

The article presents data on the development of an injectable preparation based on zinc nanoparticles. Its composition, main physical and chemical properties, toxicological assessment, application procedure and effectiveness are described.

Use of «Agrivit 5-in-1», a new injectable preparation based on vitamins and microelements is proved to be safe, helps to normalize biochemical parameters of blood and has therapeutic effectiveness for paraceratosis of piglets, the preparation increases reproductive potential of sows and viability of their breed.

The article reflects the results of the study of antimicrobial activity and toxicity of a new powder disinfectant for the sanitation of animal housing facilities.

The article discusses the use of a disinfectant based on hydrogen peroxide in industrial livestock farming conditions, and describes the scheme for its use for treating surfaces in the absence of animals and sanitizing premises in the presence of young cattle.